Early prediction of histopathological response of locally advanced rectal cancer after 1 week of preoperative radiochemotherapy using 18FDG PET-CT imaging: a prospective clinical validation study

Early prediction of histopathological response of locally advanced rectal cancer after 1 week of preoperative radiochemotherapy using 18FDG PET-CT imaging: a prospective clinical validation study

Abstract Background Neoadjuvant (preoperative) radiochemotherapy (nRCT) is a standard of care in locally advanced rectal cancer (LARC). Several studies have shown that the decline in 18FDG uptake after 2 weeks of nRCT compared with the baseline, i.e. the tumor’s metabolic response, may correlate wit...

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Bibliographic Details
Main Authors: Yulia Kundel, Zoya Cohen, Noa Gordon, Aaron Sulkes, Sara Morgenstern, Gali Perl, Nir Wasserberg, David Groshar, Hanna Bernstine, Baruch Brenner
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Radiation Oncology
Subjects:
Radiochemotherapy
Locally advanced rectal cancer
PET-CT
Response prediction
Validation
Online Access:https://doi.org/10.1186/s13014-025-02703-x
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https://doi.org/10.1186/s13014-025-02703-x

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