In Silico Design of Novel Piperazine-Based mTORC1 Inhibitors Through DFT, QSAR and ADME Investigations

In Silico Design of Novel Piperazine-Based mTORC1 Inhibitors Through DFT, QSAR and ADME Investigations

Mammalian target of rapamycin complex 1 (mTORC1) is an important and promising alternative biological target for the treatment of different types of cancer including breast, lung and renal cell carcinoma. This study contributed to the development of mathematical models highlighting the quantitative...

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Bibliographic Details
Main Authors: El Mehdi Karim, Oussama Abchir, Hassan Nour, Ossama Daoui, Souad El Khattabi, Farhan Siddique, M’Hammed El Kouali, Mohammed Talbi, Abdelkbir Errougui, Samir Chtita
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biophysica
Subjects:
2D-QSAR
anti-cancer
mTORC1 Inhibitors
piperazine derivatives
DFT
ADME
Online Access:https://www.mdpi.com/2673-4125/4/4/34
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