PrimerX: A Bayesian Multistage Cohort Embedded Randomised Trial to Evaluate the Role of Deferred Local Therapy of the Primary Tumour in Combination with Immune Checkpoint Inhibitor–based First-line Therapy in Metastatic Renal Cell Carcinoma Patients

PrimerX: A Bayesian Multistage Cohort Embedded Randomised Trial to Evaluate the Role of Deferred Local Therapy of the Primary Tumour in Combination with Immune Checkpoint Inhibitor–based First-line Therapy in Metastatic Renal Cell Carcinoma Patients

Background: Historically, patients with metastatic renal cell carcinoma (mRCC) have been offered upfront cytoreductive nephrectomy (CN) followed by systemic therapy. Currently, CN is no longer the standard of care (SOC) based on the randomised phase 3 CARMENA study performed in the vascular endothel...

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Main Authors: Orlane Figaroa, Patricia Zondervan, Rob Kessels, Johannes Berkhof, Maureen Aarts, Paul Hamberg, Maartje Los, Djura Piersma, Bart Rikhof, Britt Suelmann, Metin Tascilar, Astrid van der Veldt, Paul Verhagen, Hans Westgeest, Hilin Yildirim, Axel Bex, Adriaan Bins
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Urology Open Science
Subjects:
Checkpoint inhibitors
Deferred cytoreductive nephrectomy
Immunotherapy
Renal cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168324009200
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