Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition

Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition

Abstract Gene duplication generates gene paralogs that may undergo diverse fates during evolution, and thus serves as a potent catalyst of biological complexity. Genetic paralogs frequently share redundant functions and may also exhibit antagonistic activities by competing for common interaction par...

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Main Authors: Wei Yang, Shaobo Cong, Ruoyao Li, Jennifer Schwarz, Thilo Schulze, Raban A. Gevelhoff, Xinyan Chen, Sara Ullrich, Kristina Falkenstein, Denis Ott, Pia Eixmann, Angelica Trentino, Antje Thien, Thierry Heidmann, Ekkehard Schulze, Bettina Warscheid, Ralf Baumeister, Wenjing Qi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61626-z
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https://doi.org/10.1038/s41467-025-61626-z

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