Progress in nanomedicine for sonodynamic immunotherapy of tumors
Cancer remains a leading cause of mortality worldwide, with conventional treatments, such as chemotherapy and immunotherapy, exhibiting limitations, such as drug resistance and immune evasion. Therefore, novel therapeutic strategies are required. Sonodynamic therapy has emerged as an innovative appr...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-09-01
|
| Series: | EngMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950489924000277 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841545892438474752 |
|---|---|
| author | Ziyan Feng Ziyao Wang Xi Xiang Liyun Wang Fangxue Du Xueyang Xiao Bihui Zhu Xiao Rong Li Qiu |
| author_facet | Ziyan Feng Ziyao Wang Xi Xiang Liyun Wang Fangxue Du Xueyang Xiao Bihui Zhu Xiao Rong Li Qiu |
| author_sort | Ziyan Feng |
| collection | DOAJ |
| description | Cancer remains a leading cause of mortality worldwide, with conventional treatments, such as chemotherapy and immunotherapy, exhibiting limitations, such as drug resistance and immune evasion. Therefore, novel therapeutic strategies are required. Sonodynamic therapy has emerged as an innovative approach in which sonosensitizers are activated by ultrasound to achieve antitumor effects through mechanisms, such as cavitation, thermal effects, and reactive oxygen species generation. Notably, sonodynamic therapy also exhibits immunomodulatory effects and strongly impacts the tumor microenvironment and immune system in the body. The immune effects of sonodynamic therapy indicate that it can be applied with immunotherapy to exert synergistic effects. This review describes the design of sonosensitizers and basic mechanisms of sonodynamic therapy, highlighting their immune effects and recent advancements in sonodynamic therapy-based cancer immunotherapy. In addition, we introduce the applications of gas and metabolic regulation therapies in sonodynamic immunotherapy. |
| format | Article |
| id | doaj-art-34302ae24702409bbe35794556b5c449 |
| institution | Kabale University |
| issn | 2950-4899 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EngMedicine |
| spelling | doaj-art-34302ae24702409bbe35794556b5c4492025-01-11T06:42:28ZengElsevierEngMedicine2950-48992024-09-0112100027Progress in nanomedicine for sonodynamic immunotherapy of tumorsZiyan Feng0Ziyao Wang1Xi Xiang2Liyun Wang3Fangxue Du4Xueyang Xiao5Bihui Zhu6Xiao Rong7Li Qiu8Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaCorresponding author.; Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaCorresponding author.; Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, ChinaCancer remains a leading cause of mortality worldwide, with conventional treatments, such as chemotherapy and immunotherapy, exhibiting limitations, such as drug resistance and immune evasion. Therefore, novel therapeutic strategies are required. Sonodynamic therapy has emerged as an innovative approach in which sonosensitizers are activated by ultrasound to achieve antitumor effects through mechanisms, such as cavitation, thermal effects, and reactive oxygen species generation. Notably, sonodynamic therapy also exhibits immunomodulatory effects and strongly impacts the tumor microenvironment and immune system in the body. The immune effects of sonodynamic therapy indicate that it can be applied with immunotherapy to exert synergistic effects. This review describes the design of sonosensitizers and basic mechanisms of sonodynamic therapy, highlighting their immune effects and recent advancements in sonodynamic therapy-based cancer immunotherapy. In addition, we introduce the applications of gas and metabolic regulation therapies in sonodynamic immunotherapy.http://www.sciencedirect.com/science/article/pii/S2950489924000277Sonodynamic therapyImmunotherapyImmunogenic cell deathRegulated cell deathGas therapy |
| spellingShingle | Ziyan Feng Ziyao Wang Xi Xiang Liyun Wang Fangxue Du Xueyang Xiao Bihui Zhu Xiao Rong Li Qiu Progress in nanomedicine for sonodynamic immunotherapy of tumors EngMedicine Sonodynamic therapy Immunotherapy Immunogenic cell death Regulated cell death Gas therapy |
| title | Progress in nanomedicine for sonodynamic immunotherapy of tumors |
| title_full | Progress in nanomedicine for sonodynamic immunotherapy of tumors |
| title_fullStr | Progress in nanomedicine for sonodynamic immunotherapy of tumors |
| title_full_unstemmed | Progress in nanomedicine for sonodynamic immunotherapy of tumors |
| title_short | Progress in nanomedicine for sonodynamic immunotherapy of tumors |
| title_sort | progress in nanomedicine for sonodynamic immunotherapy of tumors |
| topic | Sonodynamic therapy Immunotherapy Immunogenic cell death Regulated cell death Gas therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2950489924000277 |
| work_keys_str_mv | AT ziyanfeng progressinnanomedicineforsonodynamicimmunotherapyoftumors AT ziyaowang progressinnanomedicineforsonodynamicimmunotherapyoftumors AT xixiang progressinnanomedicineforsonodynamicimmunotherapyoftumors AT liyunwang progressinnanomedicineforsonodynamicimmunotherapyoftumors AT fangxuedu progressinnanomedicineforsonodynamicimmunotherapyoftumors AT xueyangxiao progressinnanomedicineforsonodynamicimmunotherapyoftumors AT bihuizhu progressinnanomedicineforsonodynamicimmunotherapyoftumors AT xiaorong progressinnanomedicineforsonodynamicimmunotherapyoftumors AT liqiu progressinnanomedicineforsonodynamicimmunotherapyoftumors |