Differential impact of genetic deletion of TIGIT or PD-1 on melanoma-specific T-lymphocytes

Differential impact of genetic deletion of TIGIT or PD-1 on melanoma-specific T-lymphocytes

Immune checkpoint (IC) blockade and adoptive transfer of tumor-specific T-cells (ACT) are two major strategies to treat metastatic melanoma. Their combination can potentiate T-cell activation in the suppressive tumor microenvironment, but the autoimmune adverse effects associated with systemic injec...

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Bibliographic Details
Main Authors: Gwenann Cadiou, Tiffany Beauvais, Lucine Marotte, Sylvia Lambot, Cécile Deleine, Caroline Vignes, Malika Gantier, Melanie Hussong, Samuel Rulli, Anne Jarry, Sylvain Simon, Bernard Malissen, Nathalie Labarriere
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Adoptive cell transfer
CD8+ T cell clones
gene editing
immunotherapy
melanoma
PD-1
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2376782
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2376782

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