Supervised multi-frame dual-channel denoising enables long-term single-molecule FRET under extremely low photon budget

Supervised multi-frame dual-channel denoising enables long-term single-molecule FRET under extremely low photon budget

Abstract Camera-based single-molecule techniques have emerged as crucial tools in revolutionizing the understanding of biochemical and cellular processes due to their ability to capture dynamic processes with high precision, high-throughput capabilities, and methodological maturity. However, the str...

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Bibliographic Details
Main Authors: Yu Miao, Yuxiao Cheng, Yushi Xia, Yongzhen Hei, Wenjuan Wang, Qionghai Dai, Jinli Suo, Chunlai Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54652-w
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