Elevated serum CA 19–9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess: case report and literature review
Serum levels of the tumor marker CA 19–9 are widely utilized in the diagnosis and monitoring pancreatic and biliary malignancies. However, serum levels of CA 19–9 have also been reportedly elevated in non-malignant conditions. Here, we present the rare case of a 65-year-old woman with a history of g...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1470046/full |
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| author | Shaurya Dhingra Puneet Raman Taylor Ramsaroop Isaiah Harrison Tova Bergsten Erin Nusbaum Lawrence E. Feldman Lawrence E. Feldman |
| author_facet | Shaurya Dhingra Puneet Raman Taylor Ramsaroop Isaiah Harrison Tova Bergsten Erin Nusbaum Lawrence E. Feldman Lawrence E. Feldman |
| author_sort | Shaurya Dhingra |
| collection | DOAJ |
| description | Serum levels of the tumor marker CA 19–9 are widely utilized in the diagnosis and monitoring pancreatic and biliary malignancies. However, serum levels of CA 19–9 have also been reportedly elevated in non-malignant conditions. Here, we present the rare case of a 65-year-old woman with a history of gallbladder malignancy who was found to have a new hepatic lesion on surveillance CT with an associated elevation in CA 19–9 to 5,866 U/mL. Drainage of the lesion and treatment with antibiotics resulted in a rapid decline in CA 19–9 levels, indicating that the elevation in CA 19–9 was due to a benign hepatic lesion. We review eight similar reported cases of CA 19–9 elevations due to benign hepatic abscesses, thereby highlighting a need to interpret the tumor marker with caution. |
| format | Article |
| id | doaj-art-33c7f852b08e4166a9bf0fb1a34eef2d |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-33c7f852b08e4166a9bf0fb1a34eef2d2025-01-14T06:10:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14700461470046Elevated serum CA 19–9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess: case report and literature reviewShaurya Dhingra0Puneet Raman1Taylor Ramsaroop2Isaiah Harrison3Tova Bergsten4Erin Nusbaum5Lawrence E. Feldman6Lawrence E. Feldman7University of Illinois College of Medicine, Chicago, IL, United StatesUniversity of Illinois College of Medicine, Chicago, IL, United StatesUniversity of Illinois College of Medicine, Chicago, IL, United StatesUniversity of Illinois College of Medicine, Chicago, IL, United StatesUniversity of Illinois College of Medicine, Chicago, IL, United StatesUniversity of Illinois College of Medicine, Chicago, IL, United StatesUniversity of Illinois College of Medicine, Chicago, IL, United StatesJesse Brown VA Medical Center, Chicago, IL, United StatesSerum levels of the tumor marker CA 19–9 are widely utilized in the diagnosis and monitoring pancreatic and biliary malignancies. However, serum levels of CA 19–9 have also been reportedly elevated in non-malignant conditions. Here, we present the rare case of a 65-year-old woman with a history of gallbladder malignancy who was found to have a new hepatic lesion on surveillance CT with an associated elevation in CA 19–9 to 5,866 U/mL. Drainage of the lesion and treatment with antibiotics resulted in a rapid decline in CA 19–9 levels, indicating that the elevation in CA 19–9 was due to a benign hepatic lesion. We review eight similar reported cases of CA 19–9 elevations due to benign hepatic abscesses, thereby highlighting a need to interpret the tumor marker with caution.https://www.frontiersin.org/articles/10.3389/fmed.2024.1470046/fullCA 19–9tumor markerhepatic abscesshepatobiliaryhepatology |
| spellingShingle | Shaurya Dhingra Puneet Raman Taylor Ramsaroop Isaiah Harrison Tova Bergsten Erin Nusbaum Lawrence E. Feldman Lawrence E. Feldman Elevated serum CA 19–9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess: case report and literature review Frontiers in Medicine CA 19–9 tumor marker hepatic abscess hepatobiliary hepatology |
| title | Elevated serum CA 19–9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess: case report and literature review |
| title_full | Elevated serum CA 19–9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess: case report and literature review |
| title_fullStr | Elevated serum CA 19–9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess: case report and literature review |
| title_full_unstemmed | Elevated serum CA 19–9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess: case report and literature review |
| title_short | Elevated serum CA 19–9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess: case report and literature review |
| title_sort | elevated serum ca 19 9 level mimicking pancreaticobiliary carcinoma from a hepatic abscess case report and literature review |
| topic | CA 19–9 tumor marker hepatic abscess hepatobiliary hepatology |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1470046/full |
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