Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child
Mixed-phenotype acute leukemia (MPAL) is characterized by the expression of markers from multiple hematopoietic lineages, including myeloid, B-cell, and T-cell origins. This case report describes a 3-year, 8-month-old girl who presented with swelling in both eyes, initially accompanied by lumps on t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Applied Hematology |
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| Online Access: | https://journals.lww.com/10.4103/joah.joah_81_24 |
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| author | I Gusti Ayu Mardewi Anak Agung Wiradewi Lestari I Nyoman Wande Ni Nyoman Mahartini |
| author_facet | I Gusti Ayu Mardewi Anak Agung Wiradewi Lestari I Nyoman Wande Ni Nyoman Mahartini |
| author_sort | I Gusti Ayu Mardewi |
| collection | DOAJ |
| description | Mixed-phenotype acute leukemia (MPAL) is characterized by the expression of markers from multiple hematopoietic lineages, including myeloid, B-cell, and T-cell origins. This case report describes a 3-year, 8-month-old girl who presented with swelling in both eyes, initially accompanied by lumps on the neck and a fever that subsided with antipyretics. After the neck lumps resolved, eye swelling began in the right eye and later progressed to the left eye. Bone marrow aspiration confirmed the presence of mixed-lineage leukemia, revealing myeloblasts with Auer rod, monoblast, and lymphoblast. Leukemia phenotyping identified a mixed lineage involving myeloid, B-cell, and T-cell markers, supporting the diagnosis of MPAL. The patient was treated according to the acute lymphoblastic leukemia induction therapy protocol with vincristine and daunorubicin, and fluid hydration and allopurinol were taken to prevent tumor lysis syndrome. This case highlights the diagnostic complexity and need for a comprehensive treatment approach in managing MPAL. |
| format | Article |
| id | doaj-art-33bacb64382a472d93807428aaa61c31 |
| institution | Kabale University |
| issn | 1658-5127 2454-6976 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Applied Hematology |
| spelling | doaj-art-33bacb64382a472d93807428aaa61c312025-01-10T11:14:49ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272454-69762024-12-0115431932510.4103/joah.joah_81_24Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old ChildI Gusti Ayu MardewiAnak Agung Wiradewi LestariI Nyoman WandeNi Nyoman MahartiniMixed-phenotype acute leukemia (MPAL) is characterized by the expression of markers from multiple hematopoietic lineages, including myeloid, B-cell, and T-cell origins. This case report describes a 3-year, 8-month-old girl who presented with swelling in both eyes, initially accompanied by lumps on the neck and a fever that subsided with antipyretics. After the neck lumps resolved, eye swelling began in the right eye and later progressed to the left eye. Bone marrow aspiration confirmed the presence of mixed-lineage leukemia, revealing myeloblasts with Auer rod, monoblast, and lymphoblast. Leukemia phenotyping identified a mixed lineage involving myeloid, B-cell, and T-cell markers, supporting the diagnosis of MPAL. The patient was treated according to the acute lymphoblastic leukemia induction therapy protocol with vincristine and daunorubicin, and fluid hydration and allopurinol were taken to prevent tumor lysis syndrome. This case highlights the diagnostic complexity and need for a comprehensive treatment approach in managing MPAL.https://journals.lww.com/10.4103/joah.joah_81_24mixed-phenotype acute leukemiapediatric leukemiatrilineage differentiation |
| spellingShingle | I Gusti Ayu Mardewi Anak Agung Wiradewi Lestari I Nyoman Wande Ni Nyoman Mahartini Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child Journal of Applied Hematology mixed-phenotype acute leukemia pediatric leukemia trilineage differentiation |
| title | Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child |
| title_full | Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child |
| title_fullStr | Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child |
| title_full_unstemmed | Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child |
| title_short | Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child |
| title_sort | mixed phenotype acute leukemia with trilineage differentiation in a 3 year old child |
| topic | mixed-phenotype acute leukemia pediatric leukemia trilineage differentiation |
| url | https://journals.lww.com/10.4103/joah.joah_81_24 |
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