25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression
Background. There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with ne...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/904876 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849306041852887040 |
|---|---|
| author | Corina-Daniela Ene Amalia-Elena Anghel Monica Neagu Ilinca Nicolae |
| author_facet | Corina-Daniela Ene Amalia-Elena Anghel Monica Neagu Ilinca Nicolae |
| author_sort | Corina-Daniela Ene |
| collection | DOAJ |
| description | Background. There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL-8, angiogenic factor, and vitamin D is still at the dawn of research. Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL-8, and metabolic ones, such as vitamin D. These candidate biomarkers are intended to aid classical biomarkers, such as LDH, in the prognosis of cutaneous melanoma. Methods. Serum vitamin D and IL-8 were quantified in melanoma patients and in matching healthy controls. Results. Median serum vitamin D concentrations were significantly lower (p=0.003) in melanoma patients as compared to healthy control subjects, while around 65% of the investigated patients have proven a severe circulatory deficiency of this vitamin. IL-8 was found increased (p=0.001) in melanoma patients as compared to controls. Conclusion. Upregulation of proangiogenic factors associated with vitamin D deficiency can prove to be potent future biomarkers candidates, enhancing the predictive power of classical LDH. |
| format | Article |
| id | doaj-art-3399d68f0fdb410d9fbf63a821c35d2f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3399d68f0fdb410d9fbf63a821c35d2f2025-08-20T03:55:12ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/90487690487625-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and ProgressionCorina-Daniela Ene0Amalia-Elena Anghel1Monica Neagu2Ilinca Nicolae3Nephrology Hospital “Dr. Carol Davila”, 4 Calea Grivitei, 010731 Bucharest, RomaniaSKINMED Clinic, 8 Splaiul Unirii, 040102 Bucharest, RomaniaImmunology Department, Victor Babes National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaDepartment in Dermatology, Infectious and Tropical Diseases “Dr. Victor Babeş” Clinical Hospital-Research, 281 Soseaua Mihai Bravu, 030303 Bucharest, RomaniaBackground. There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL-8, angiogenic factor, and vitamin D is still at the dawn of research. Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL-8, and metabolic ones, such as vitamin D. These candidate biomarkers are intended to aid classical biomarkers, such as LDH, in the prognosis of cutaneous melanoma. Methods. Serum vitamin D and IL-8 were quantified in melanoma patients and in matching healthy controls. Results. Median serum vitamin D concentrations were significantly lower (p=0.003) in melanoma patients as compared to healthy control subjects, while around 65% of the investigated patients have proven a severe circulatory deficiency of this vitamin. IL-8 was found increased (p=0.001) in melanoma patients as compared to controls. Conclusion. Upregulation of proangiogenic factors associated with vitamin D deficiency can prove to be potent future biomarkers candidates, enhancing the predictive power of classical LDH.http://dx.doi.org/10.1155/2015/904876 |
| spellingShingle | Corina-Daniela Ene Amalia-Elena Anghel Monica Neagu Ilinca Nicolae 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression Mediators of Inflammation |
| title | 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression |
| title_full | 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression |
| title_fullStr | 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression |
| title_full_unstemmed | 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression |
| title_short | 25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression |
| title_sort | 25 oh vitamin d and interleukin 8 emerging biomarkers in cutaneous melanoma development and progression |
| url | http://dx.doi.org/10.1155/2015/904876 |
| work_keys_str_mv | AT corinadanielaene 25ohvitamindandinterleukin8emergingbiomarkersincutaneousmelanomadevelopmentandprogression AT amaliaelenaanghel 25ohvitamindandinterleukin8emergingbiomarkersincutaneousmelanomadevelopmentandprogression AT monicaneagu 25ohvitamindandinterleukin8emergingbiomarkersincutaneousmelanomadevelopmentandprogression AT ilincanicolae 25ohvitamindandinterleukin8emergingbiomarkersincutaneousmelanomadevelopmentandprogression |