Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity

Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity

Abstract Extracellular matrices of living tissues exhibit viscoelastic properties, yet how these properties regulate chromatin and the epigenome remains unclear. Here, we show that viscoelastic substrates induce changes in nuclear architecture and epigenome, with more pronounced effects on softer su...

Full description

Saved in:
Bibliographic Details
Main Authors: Yifan Wu, Yang Song, Jennifer Soto, Tyler Hoffman, Xiao Lin, Aaron Zhang, Siyu Chen, Ramzi N. Massad, Xiao Han, Dongping Qi, Kun-Wei Yeh, Zhiwei Fang, Joon Eoh, Luo Gu, Amy C. Rowat, Zhen Gu, Song Li
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59190-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-025-59190-7

Similar Items