Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma
Introduction Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. As the median survival for patients with mesothelioma is 12.1 months, surgery is an important consideration to improve survival and/or quality...
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2020-09-01
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| author | Liz Darlison John Edwards Apostolos Nakas Nick A Maskell Wendy Underwood Chris Rogers Matthew Callister David Waller Richard Milton Victoria Ashford-Turner Paul Taylor Claire Matthews Victoria Hughes Kelvin Lau Alan Kirk Robert C Rintoul Elizabeth A Stokes Kate Ashton Daisy Elliott Rosie Harris Marie Kirwan Juliette Novasio Sara Waplington Eric Lim Holly Mckeon Charlotte Jacobs Laura White Mary O’Brien Judith Moore Louise Li Nicola Mills Sanjay Popat Suzanne Miller Nadia Yousaf D A Fennell Clinton Ali Andrea Bille Liz Fuller Andreea Ionescu Manjusha Keni Pek Koh Talal Mansy Dakshinamoorthy Muthukumar Tony Pope Amy Roy Riyaz Shah Jonathan Shamash Zacharias Tasigiannopoulos Sarah Treece Katherine Joyce Barbara Warnes Athanasia Gravani Rachel Brophy Nicola Farrar Jane Elliott Philip Noyes Louise Nelson Sara Tenconi Laura Socci Hilary Wood Helena Hanratty Helena Stanley Robert Rintoul Amy Gladwell Jenny Castedo Amanda Stone Charlotte Ingle Hayley Hewer Eleanor Aynsley Andrea Watson Alison Hassall Masuma Begum Christopher Worth Ellie Piggott Elizabeth Nadin Yvonne Summers Raffaele Califano Laura Cove-Smith Matt Evison Maria Blinston Amal Ismail Rachel Chant Asmita Desai Ian Morgan Victoria Lake Nichola Harris Simon Hodge Nadza Tokaca Adam Januszewski Avani Athauda Anisha Ramessur Emily Grist Niamh Colman Michael Flynn Joan Joyce Sarah Vaughan Maria Piga Derya Sahin Agnieszka Yongue Emma Turay Jaishree Bhosle Rajiv Kumar Charlotte Milner-Watts Jessica Brown David Walder Alexandros Georgiou Xiaorong Wu Naila Kaudeer Kroopa Joshi Michael Davidson Shelize Khakoo Bee Ayite Kathryn Priest James Dobbyn Vasanthi Prathapan Deborah McCrimmon Natalie Ash Alison Norton Bianca Peet Libby Hennessy Rosemary Johnson |
| author_facet | Liz Darlison John Edwards Apostolos Nakas Nick A Maskell Wendy Underwood Chris Rogers Matthew Callister David Waller Richard Milton Victoria Ashford-Turner Paul Taylor Claire Matthews Victoria Hughes Kelvin Lau Alan Kirk Robert C Rintoul Elizabeth A Stokes Kate Ashton Daisy Elliott Rosie Harris Marie Kirwan Juliette Novasio Sara Waplington Eric Lim Holly Mckeon Charlotte Jacobs Laura White Mary O’Brien Judith Moore Louise Li Nicola Mills Sanjay Popat Suzanne Miller Nadia Yousaf D A Fennell Clinton Ali Andrea Bille Liz Fuller Andreea Ionescu Manjusha Keni Pek Koh Talal Mansy Dakshinamoorthy Muthukumar Tony Pope Amy Roy Riyaz Shah Jonathan Shamash Zacharias Tasigiannopoulos Sarah Treece Katherine Joyce Barbara Warnes Athanasia Gravani Rachel Brophy Nicola Farrar Jane Elliott Philip Noyes Louise Nelson Sara Tenconi Laura Socci Hilary Wood Helena Hanratty Helena Stanley Robert Rintoul Amy Gladwell Jenny Castedo Amanda Stone Charlotte Ingle Hayley Hewer Eleanor Aynsley Andrea Watson Alison Hassall Masuma Begum Christopher Worth Ellie Piggott Elizabeth Nadin Yvonne Summers Raffaele Califano Laura Cove-Smith Matt Evison Maria Blinston Amal Ismail Rachel Chant Asmita Desai Ian Morgan Victoria Lake Nichola Harris Simon Hodge Nadza Tokaca Adam Januszewski Avani Athauda Anisha Ramessur Emily Grist Niamh Colman Michael Flynn Joan Joyce Sarah Vaughan Maria Piga Derya Sahin Agnieszka Yongue Emma Turay Jaishree Bhosle Rajiv Kumar Charlotte Milner-Watts Jessica Brown David Walder Alexandros Georgiou Xiaorong Wu Naila Kaudeer Kroopa Joshi Michael Davidson Shelize Khakoo Bee Ayite Kathryn Priest James Dobbyn Vasanthi Prathapan Deborah McCrimmon Natalie Ash Alison Norton Bianca Peet Libby Hennessy Rosemary Johnson |
| collection | DOAJ |
| description | Introduction Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. As the median survival for patients with mesothelioma is 12.1 months, surgery is an important consideration to improve survival and/or quality of life. Currently, only two surgical trials have been performed which found that neither extensive (extra-pleural pneumonectomy) or limited (partial pleurectomy) surgery improved survival (although there was some evidence of improved quality of life). Therefore, clinicians are now looking to evaluate pleurectomy decortication, the only radical treatment option left.Methods and analysis The MARS 2 study is a UK multicentre open parallel group randomised controlled trial comparing the effectiveness and cost-effectiveness of surgery—(extended) pleurectomy decortication—versus no surgery for the treatment of pleural mesothelioma. The study will test the hypothesis that surgery and chemotherapy is superior to chemotherapy alone with respect to overall survival. Secondary outcomes include health-related quality of life, progression-free survival, measures of safety (adverse events) and resource use to 2 years. The QuinteT Recruitment Intervention is integrated into the trial to optimise recruitment.Ethics and dissemination Research ethics approval was granted by London – Camberwell St. Giles Research Ethics Committee (reference 13/LO/1481) on 7 November 2013. We will submit the results for publication in a peer-reviewed journal.Trial registration numbers ISRCTN—ISRCTN44351742 and ClinicalTrials.gov—NCT02040272. |
| format | Article |
| id | doaj-art-32fc85f80c044e6eb4476952c3c0a85c |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-32fc85f80c044e6eb4476952c3c0a85c2025-01-08T21:10:12ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2020-038892Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma 0Liz Darlison1John Edwards2Apostolos NakasNick A Maskell3Wendy UnderwoodChris Rogers4Matthew Callister5David Waller6Richard Milton7Victoria Ashford-Turner8Paul Taylor9Claire Matthews10Victoria Hughes11Kelvin Lau12Alan Kirk13Robert C Rintoul14Elizabeth A Stokes15Kate Ashton16Daisy Elliott17Rosie Harris18Marie KirwanJuliette NovasioSara WaplingtonEric Lim19Holly Mckeon20Charlotte JacobsLaura White21Mary O’BrienJudith MooreLouise LiNicola Mills22Sanjay Popat23Suzanne Miller24Nadia YousafD A Fennell25Clinton Ali26Andrea Bille27Liz Fuller28Andreea Ionescu29Manjusha Keni30Pek Koh31Talal Mansy32Dakshinamoorthy Muthukumar33Tony Pope34Amy Roy35Riyaz Shah36Jonathan Shamash37Zacharias Tasigiannopoulos38Sarah Treece39Katherine Joyce40Barbara Warnes41Athanasia GravaniRachel Brophy42Nicola Farrar43Jane ElliottPhilip NoyesLouise NelsonSara TenconiLaura SocciHilary WoodHelena HanrattyHelena StanleyRobert RintoulAmy GladwellJenny CastedoAmanda StoneCharlotte IngleHayley HewerEleanor AynsleyAndrea WatsonAlison HassallMasuma BegumChristopher WorthEllie PiggottElizabeth NadinYvonne Summers44Raffaele CalifanoLaura Cove-SmithMatt EvisonMaria BlinstonAmal IsmailRachel ChantAsmita DesaiIan MorganVictoria LakeNichola HarrisSimon HodgeNadza TokacaAdam JanuszewskiAvani AthaudaAnisha Ramessur45Emily GristNiamh ColmanMichael Flynn46Joan JoyceSarah VaughanMaria PigaDerya SahinAgnieszka YongueEmma TurayJaishree BhosleRajiv Kumar47Charlotte Milner-WattsJessica BrownDavid WalderAlexandros GeorgiouXiaorong Wu48Naila KaudeerKroopa JoshiMichael Davidson49Shelize KhakooBee AyiteKathryn PriestJames DobbynVasanthi PrathapanDeborah McCrimmonNatalie AshAlison NortonBianca PeetLibby HennessyRosemary JohnsonGENYO, Pfizer-University, Granada, Spain, Granada, SpainMesothelioma Research Programme, University Hospitals of Leicester NHS Trust, Leicester, UK1 Digestive Health, Gold Coast University Hospital, Southport, Queensland, AustraliaAcademic Respiratory Unit, University of Bristol, Bristol, UKBristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UKLeeds Centre for Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, Leeds, UKDepartment of Thoracic Surgery, Barts Health NHS Trust, London, UKThoracic Surgery Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK9 Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK5 Sheffield Centre for Health and Related Research, The University of Sheffield, Sheffield, UK1 Papworth Trials Unit Collaboration, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK1 Papworth Trials Unit Collaboration, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UKDepartment of Thoracic Surgery, Barts Health NHS Trust, London, UKDepartment of Thoracic Surgery, Golden Jubilee National Hospital, Clydebank, UK6 Department of Oncology, University of Cambridge, Cambridge, UKHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UKBristol Trials Centre (CTEU), University of Bristol, Bristol, UKNational Institute for Health and Care Research Bristol Biomedical Research Centre, Bristol Centre for Surgical Research, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK1 Bristol Medical School, University of Bristol Faculty of Health Sciences, Bristol, UKDepartment of Thoracic Surgery, Royal Brompton Hospital, London, UKBristol Trials Centre, Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UKCR UK & UCL Cancer Trials Centre, University College London, London, UKPopulation Health Sciences, University of Bristol Medical School, Bristol, UK5 Lung Unit, Royal Marsden Hospital NHS Trust, London, UK4 Division of Respiratory Medicine, NIHR Biomedical Research Centre, Biodiscovery Institute and Nottingham Molecular Pathology Node, University of Nottingham, Nottingham, UKCancer Research UK Centre Leicester, University Hospitals of Leicester NHS Trust, Leicester, UKThe Beatson West of Scotland Cancer Centre, Gartnavel General Hospital, Glasgow, UK5 Department of Thoracic Surgery, St Thomas` Hospital, London, UKRespiratory Medicine, South Tyneside NHS Foundation Trust, South Shields, UKLung Cancer, Aneurin Bevan University Health Board, Newport, UKOncology, Derby Teaching Hospitals NHS Foundation Trust, Derby, UKDepartment of Oncology, New Cross Hospital, Wolverhampton, UKOncology, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UKOncology, Colchester Hospital University NHS Foundation Trust, Colchester, UKClatterbridge Cancer Centre, Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, UK13 Department of Medical Oncology, University Hospitals Plymouth NHS Trust, Plymouth, UK10 Department of Medical Oncology, Kent Oncology Centre, Maidstone, UKDepartment of Medical Oncology, Barts Health NHS Trust, London, UKThe Oncology Care Team, Norfolk and Norwich University Hospital NHS Trust, Norwich, UKHeamatology and Oncology Unit, North West Anglia NHS Foundation Trust, Peterborough, UKBristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK, University of Bristol, Bristol, UK1 Bristol Medical School, University of Bristol Faculty of Health Sciences, Bristol, UKCentre for Public Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK1 Bristol Medical School, University of Bristol Faculty of Health Sciences, Bristol, UKMedical Oncology, The Christie NHS Foundation Trust, Manchester, Manchester, UKThe Royal Marsden Hospital NHS Foundation Trust, London, UKMedical Oncology, University College London Hospitals NHS Foundation Trust, London, UKPathology, Army Hospital Research and Referral, New Delhi, Delhi, IndiaDepartment of Urology, RenJi Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, ChinaThe Royal Marsden Hospital NHS Foundation Trust, London, UKIntroduction Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. As the median survival for patients with mesothelioma is 12.1 months, surgery is an important consideration to improve survival and/or quality of life. Currently, only two surgical trials have been performed which found that neither extensive (extra-pleural pneumonectomy) or limited (partial pleurectomy) surgery improved survival (although there was some evidence of improved quality of life). Therefore, clinicians are now looking to evaluate pleurectomy decortication, the only radical treatment option left.Methods and analysis The MARS 2 study is a UK multicentre open parallel group randomised controlled trial comparing the effectiveness and cost-effectiveness of surgery—(extended) pleurectomy decortication—versus no surgery for the treatment of pleural mesothelioma. The study will test the hypothesis that surgery and chemotherapy is superior to chemotherapy alone with respect to overall survival. Secondary outcomes include health-related quality of life, progression-free survival, measures of safety (adverse events) and resource use to 2 years. The QuinteT Recruitment Intervention is integrated into the trial to optimise recruitment.Ethics and dissemination Research ethics approval was granted by London – Camberwell St. Giles Research Ethics Committee (reference 13/LO/1481) on 7 November 2013. We will submit the results for publication in a peer-reviewed journal.Trial registration numbers ISRCTN—ISRCTN44351742 and ClinicalTrials.gov—NCT02040272.https://bmjopen.bmj.com/content/10/9/e038892.full |
| spellingShingle | Liz Darlison John Edwards Apostolos Nakas Nick A Maskell Wendy Underwood Chris Rogers Matthew Callister David Waller Richard Milton Victoria Ashford-Turner Paul Taylor Claire Matthews Victoria Hughes Kelvin Lau Alan Kirk Robert C Rintoul Elizabeth A Stokes Kate Ashton Daisy Elliott Rosie Harris Marie Kirwan Juliette Novasio Sara Waplington Eric Lim Holly Mckeon Charlotte Jacobs Laura White Mary O’Brien Judith Moore Louise Li Nicola Mills Sanjay Popat Suzanne Miller Nadia Yousaf D A Fennell Clinton Ali Andrea Bille Liz Fuller Andreea Ionescu Manjusha Keni Pek Koh Talal Mansy Dakshinamoorthy Muthukumar Tony Pope Amy Roy Riyaz Shah Jonathan Shamash Zacharias Tasigiannopoulos Sarah Treece Katherine Joyce Barbara Warnes Athanasia Gravani Rachel Brophy Nicola Farrar Jane Elliott Philip Noyes Louise Nelson Sara Tenconi Laura Socci Hilary Wood Helena Hanratty Helena Stanley Robert Rintoul Amy Gladwell Jenny Castedo Amanda Stone Charlotte Ingle Hayley Hewer Eleanor Aynsley Andrea Watson Alison Hassall Masuma Begum Christopher Worth Ellie Piggott Elizabeth Nadin Yvonne Summers Raffaele Califano Laura Cove-Smith Matt Evison Maria Blinston Amal Ismail Rachel Chant Asmita Desai Ian Morgan Victoria Lake Nichola Harris Simon Hodge Nadza Tokaca Adam Januszewski Avani Athauda Anisha Ramessur Emily Grist Niamh Colman Michael Flynn Joan Joyce Sarah Vaughan Maria Piga Derya Sahin Agnieszka Yongue Emma Turay Jaishree Bhosle Rajiv Kumar Charlotte Milner-Watts Jessica Brown David Walder Alexandros Georgiou Xiaorong Wu Naila Kaudeer Kroopa Joshi Michael Davidson Shelize Khakoo Bee Ayite Kathryn Priest James Dobbyn Vasanthi Prathapan Deborah McCrimmon Natalie Ash Alison Norton Bianca Peet Libby Hennessy Rosemary Johnson Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma BMJ Open |
| title | Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma |
| title_full | Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma |
| title_fullStr | Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma |
| title_full_unstemmed | Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma |
| title_short | Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma |
| title_sort | mesothelioma and radical surgery 2 mars 2 protocol for a multicentre randomised trial comparing extended pleurectomy decortication versus no extended pleurectomy decortication for patients with malignant pleural mesothelioma |
| url | https://bmjopen.bmj.com/content/10/9/e038892.full |
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mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT helenahanratty mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT helenastanley mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT robertrintoul mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT amygladwell mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT jennycastedo mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT amandastone mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT charlotteingle mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT hayleyhewer mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT eleanoraynsley mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT andreawatson mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT alisonhassall mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT masumabegum mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT christopherworth mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT elliepiggott mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT elizabethnadin mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT yvonnesummers mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT raffaelecalifano mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT lauracovesmith mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT mattevison mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT mariablinston mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT amalismail mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT rachelchant mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT asmitadesai mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT ianmorgan mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT victorialake mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT nicholaharris mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT simonhodge mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT nadzatokaca mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT adamjanuszewski mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT avaniathauda mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT anisharamessur mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT emilygrist mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT niamhcolman mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT michaelflynn mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT joanjoyce mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT sarahvaughan mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT mariapiga mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT deryasahin mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT agnieszkayongue mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT emmaturay mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT jaishreebhosle mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT rajivkumar mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT charlottemilnerwatts mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT jessicabrown mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT davidwalder mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT alexandrosgeorgiou mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT xiaorongwu mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT nailakaudeer mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT kroopajoshi mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT michaeldavidson mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT shelizekhakoo mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT beeayite mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT kathrynpriest mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT jamesdobbyn mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT vasanthiprathapan mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT deborahmccrimmon mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT natalieash mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT alisonnorton mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT biancapeet mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT libbyhennessy mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma AT rosemaryjohnson mesotheliomaandradicalsurgery2mars2protocolforamulticentrerandomisedtrialcomparingextendedpleurectomydecorticationversusnoextendedpleurectomydecorticationforpatientswithmalignantpleuralmesothelioma |