Prognostic marker Musashi-2 modulates DNA damage response and radioresistance in diffuse large B-cell lymphoma

Prognostic marker Musashi-2 modulates DNA damage response and radioresistance in diffuse large B-cell lymphoma

IntroductionTreatment resistance is a major hurdle in diffuse large B-cell lymphoma (DLBCL) therapy. Here, we assessed the relevance of the Musashi (MSI) RNA-binding protein family for DLBCL treatment efficacy. As important gene expression regulators, these proteins have previously been associated w...

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Main Authors: Timo Habig, Lasse Reichstein, Kathrin A. Brücksken, Mark Sicking, Jan Labisch, Michael Oertel, Eberhard Korsching, Georg Lenz, Stephan Hailfinger, Burkhard Greve, Fabian M. Troschel, Hans Theodor Eich
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Musashi-2 (MSI2)
DLBCL-diffuse large B-cell lymphoma
DNA damage (DDR)
radiotherapy
NOTCH signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1575483/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1575483/full

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