ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

Abstract Phase transitions of cellular proteins and lipids play a key role in governing the organisation and coordination of intracellular biology. Recent work has raised the intriguing prospect that phase transitions in proteins and lipids can be co-regulated. Here we investigate this possibility i...

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Main Authors: Jonathon Nixon-Abell, Francesco S. Ruggeri, Seema Qamar, Therese W. Herling, Magdalena A. Czekalska, Yi Shen, Guozhen Wang, Christopher King, Michael S. Fernandopulle, Tomas Sneideris, Joseph L. Watson, Visakh V. S. Pillai, William Meadows, James W. Henderson, Joseph E. Chambers, Jane L. Wagstaff, Sioned H. Williams, Helena Coyle, Greta Šneiderienė, Yuqian Lu, Shuyuan Zhang, Stefan J. Marciniak, Stefan M. V. Freund, Emmanuel Derivery, Michael E. Ward, Michele Vendruscolo, Tuomas P. J. Knowles, Peter St George-Hyslop
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58142-5
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https://doi.org/10.1038/s41467-025-58142-5

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