Multistep Modelling and Monitoring of Bioprocesses
A new approach is proposed for modelling and monitoring bioprocesses dynamics characterized by different metabolic states. Bioprocesses cannot be described by a single model. For this reason, three phases characterised by the bioprocess are defined – periodic, exponential, and stationary. During eac...
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| Format: | Article |
| Language: | English |
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Bulgarian Academy of Sciences
2024-12-01
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| Series: | International Journal Bioautomation |
| Subjects: | |
| Online Access: | http://www.biomed.bas.bg/bioautomation/2024/vol_28.4/files/28.4_01.pdf |
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| _version_ | 1841553364692762624 |
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| author | Velislava Lyubenova Maya Ignatova Denitsa Kristeva Olympia Roeva |
| author_facet | Velislava Lyubenova Maya Ignatova Denitsa Kristeva Olympia Roeva |
| author_sort | Velislava Lyubenova |
| collection | DOAJ |
| description | A new approach is proposed for modelling and monitoring bioprocesses dynamics characterized by different metabolic states. Bioprocesses cannot be described by a single model. For this reason, three phases characterised by the bioprocess are defined – periodic, exponential, and stationary. During each phase, the process passes through one or more physiological states. Each physiological state is described by a sub-model with a different structure and parameter values. The transition of the process from one physiological state to another is carried out by switching the sub-models based on a predefined key parameter. Monitoring is performed by a cascade of software sensors using the sub-models and real-time measurement of the concentrations of the main process variables. The proposed approach was tested by modelling and monitoring the Escherichia coli phytase production process. |
| format | Article |
| id | doaj-art-32badad9b2af46169a8858bbc1178810 |
| institution | Kabale University |
| issn | 1314-1902 1314-2321 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Bulgarian Academy of Sciences |
| record_format | Article |
| series | International Journal Bioautomation |
| spelling | doaj-art-32badad9b2af46169a8858bbc11788102025-01-09T10:27:31ZengBulgarian Academy of SciencesInternational Journal Bioautomation1314-19021314-23212024-12-0128418519610.7546/ijba.2024.28.4.001033Multistep Modelling and Monitoring of BioprocessesVelislava Lyubenova0Maya IgnatovaDenitsa KristevaOlympia RoevaInstitute of Robotics, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Science, Sofia, Bulgaria A new approach is proposed for modelling and monitoring bioprocesses dynamics characterized by different metabolic states. Bioprocesses cannot be described by a single model. For this reason, three phases characterised by the bioprocess are defined – periodic, exponential, and stationary. During each phase, the process passes through one or more physiological states. Each physiological state is described by a sub-model with a different structure and parameter values. The transition of the process from one physiological state to another is carried out by switching the sub-models based on a predefined key parameter. Monitoring is performed by a cascade of software sensors using the sub-models and real-time measurement of the concentrations of the main process variables. The proposed approach was tested by modelling and monitoring the Escherichia coli phytase production process.http://www.biomed.bas.bg/bioautomation/2024/vol_28.4/files/28.4_01.pdfmodellingmonitoringbioprocessesescherichia coli |
| spellingShingle | Velislava Lyubenova Maya Ignatova Denitsa Kristeva Olympia Roeva Multistep Modelling and Monitoring of Bioprocesses International Journal Bioautomation modelling monitoring bioprocesses escherichia coli |
| title | Multistep Modelling and Monitoring of Bioprocesses |
| title_full | Multistep Modelling and Monitoring of Bioprocesses |
| title_fullStr | Multistep Modelling and Monitoring of Bioprocesses |
| title_full_unstemmed | Multistep Modelling and Monitoring of Bioprocesses |
| title_short | Multistep Modelling and Monitoring of Bioprocesses |
| title_sort | multistep modelling and monitoring of bioprocesses |
| topic | modelling monitoring bioprocesses escherichia coli |
| url | http://www.biomed.bas.bg/bioautomation/2024/vol_28.4/files/28.4_01.pdf |
| work_keys_str_mv | AT velislavalyubenova multistepmodellingandmonitoringofbioprocesses AT mayaignatova multistepmodellingandmonitoringofbioprocesses AT denitsakristeva multistepmodellingandmonitoringofbioprocesses AT olympiaroeva multistepmodellingandmonitoringofbioprocesses |