Mining the heparinome for cryptic antimicrobial peptides that selectively kill Gram-negative bacteria

Mining the heparinome for cryptic antimicrobial peptides that selectively kill Gram-negative bacteria

Abstract Glycosaminoglycan (GAG)-binding proteins regulating essential processes such as cell growth and migration are essential for cell homeostasis. As both GAGs and the lipid A disaccharide core of Gram-negative bacteria contain negatively charged disaccharide units, we hypothesized that GAG-bind...

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Bibliographic Details
Main Authors: Roberto Bello-Madruga, Daniel Sandín, Javier Valle, Jordi Gómez, Laura Comas, María Nieves Larrosa, Juan José González-López, María Ángeles Jiménez, David Andreu, Marc Torrent
Format: Article
Language:English
Published: Springer Nature 2025-05-01
Series:Molecular Systems Biology
Subjects:
Antimicrobial Peptide
Heparin-binding Protein
Lipopolysaccharide
Heparin
Glycosaminoglycans
Online Access:https://doi.org/10.1038/s44320-025-00120-6
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https://doi.org/10.1038/s44320-025-00120-6

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