Comprehensive multi-omics analysis uncovers potential risks of aged sperm on offspring development after short-term storage

Comprehensive multi-omics analysis uncovers potential risks of aged sperm on offspring development after short-term storage

Abstract Background Recent studies have demonstrated that prolonged sperm storage adversely affects offspring through epigenetics, yet its broader effects on other molecular levels such as transcription and proteomics in progeny have been rarely explored. Results We employed comprehensive multi-omic...

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Main Authors: Yu Cheng, Songpei Zhang, Sayyed Mohammad Hadi Alavi, Rigolin Nayak, Swapnil Gorakh Waghmare, Nururshopa Eskander Shazada, Deepali Rahi Roy, Zhijun Ma, Otomar Linhart, Zuzana Linhartová
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
Epigenetics
Fish sperm
Sperm ageing
Offspring development
Epigenetic inheritance
Online Access:https://doi.org/10.1186/s12915-025-02379-5
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https://doi.org/10.1186/s12915-025-02379-5

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