Structure-based virtual screening of natural compounds in preventing skin senescence: The role of epigallocatechin gallate in protein kinase C alpha-specific inhibition against UV-induced photoaging

Structure-based virtual screening of natural compounds in preventing skin senescence: The role of epigallocatechin gallate in protein kinase C alpha-specific inhibition against UV-induced photoaging

This study combines high-throughput screening and virtual molecular docking to identify natural compounds targeting PKC in skin aging. Go 6983, a PKC inhibitor, showed potent suppression of MMP-1 transcription. EGCG was one of the candidates that showed it could significantly lower UVB-induced MMP-1...

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Bibliographic Details
Main Authors: Cheol Hyeon Cho, Woo-Jin Sim, Nam-Chul Cho, Wonchul Lim, Tae-Gyu Lim
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
Anti-skin aging
High-throughput screening
Human skin
Protein kinase C
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024159646
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http://www.sciencedirect.com/science/article/pii/S2405844024159646

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