Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery

Abstract Background Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effe...

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Main Authors: Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Genome Medicine
Subjects:
Network pharmacology
Pharmacogenomics
Cheminformatics
Connectivity mapping
CMap
Cell type-specific
Online Access:https://doi.org/10.1186/s13073-025-01431-x
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https://doi.org/10.1186/s13073-025-01431-x

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