Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

Summary: Tank-binding kinase 1 (TBK1) is a critical signal transducer in the nuclear factor κB (NF-κB) and interferon regulatory factor (IRF) pathways, essential for innate immunity. However, its negative regulation mechanisms remain unclear. This study demonstrates that TBK1 succinylation, regulate...

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Main Authors: Xuedi Zhang, Chunxiu Ling, Ziying Xiong, Ting Gong, Shuhua Luo, Xiaolei Liu, Lina Zhang, Chaoxiong Liao, Yue Lu, Xiao Huang, Wending Zhou, Shuangnan Zhou, Youtan Liu, Jing Tang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014116
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