The effects of coenzyme q10 on testes of rats with diabetes induced by streptozotocin
<b>Aim:</b> In this study, it was aimed to determine the effect of CoQ<sub>10</sub> on testes in streptozotocin (STZ) induced diabetic rats.<p> <b>Materials and Methods: </b>In this study, thirty-four adult male Wistar Albino rats were used. The animals were...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2021-12-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1369 |
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| Summary: | <b>Aim:</b> In this study, it was aimed to determine the effect of CoQ<sub>10</sub> on testes
in streptozotocin (STZ) induced diabetic rats.<p>
<b>Materials and Methods: </b>In this study, thirty-four adult male Wistar Albino
rats were used. The animals were divided into five groups: Control
group (K), oil group (Y; daily intraperitoneal injection of 0,3 ml corn oil),
CoQ<sub>10</sub> group (CoQ<sub>10</sub>; daily intraperitoneal injection of 10 mg/kg CoQ<sub>10</sub>), Diabetes
group (D; subcutan injection of 40 mg/kg STZ, single daily dose for
two days), and Diabetes+ CoQ<sub>10</sub> group (D+CoQ<sub>10</sub>; Diabetic rats was injected
daily intraperitoneally 10 mg/kg CoQ<sub>10</sub>). At the end of fourth week, tissue
samples were obtained from sacrified animals. Testes were weighed, then
fixed in Bouin's solution and processed by means of routine histological
techniques. Sections were stained with H&E staining method to determine
the general histological structure. Also, PCNA reactivity was determined
by immunohistochemical method.<p>
<b>Results: </b>The mean body weight was significantly decreased in diabetes
and diabetes+ CoQ<sub>10</sub> groups when compared to control, oil and CoQ<sub>10</sub>
groups but the gonadosomatic index (GSI) was found higher in diabetes
groups (p<0.05). Mean seminiferous tubular diameter (STD), height of
germinal epithelium (GEH) and PCNA index were significantly reduced in
diabetes groups in comparison with control, oil, CoQ<sub>10</sub> and diabetes+CoQ<sub>10</sub>
groups (p<0.05). In diabetes+CoQ<sub>10</sub> group showed significantly increase in
STD, GEH and PCNA index compared to diabetes group (p<0.05).<p>
<b>Conclusion: </b>In conclusion, CoQ<sub>10</sub> play a role in reducing the cellular damages
caused by diabetes. |
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| ISSN: | 1309-6958 2146-1953 |