miRNA-21和miRNA-134在乳腺癌患者血清中表达情况及其临床意义
[目的] 研究乳腺癌相关miRNA在正常人群及乳腺癌患者血清中的表达情况,统计分析其在乳腺癌诊断中的临床价值。[方法] 收集47例乳腺癌及50例正常体检人群血清,通过实时荧光定量PCR(RT-PCR)检测各组miR-630、miR-21、miR-195、miR-134 、miR-200a、miR-381、miR-1228的表达情况。分析单个血清miRNA在乳腺癌诊断中的价值,进一步用统计学方法分析多个miRNA联合检测的诊断价值。[结果]相比正常体检人群,乳腺癌患者血清中miR134和miR21表达增加,P<0.01;miR-134的表达在早期和晚期患者之间没有明显区别,P=0.143;...
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Main Author: | 石岩 |
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Format: | Article |
Language: | zho |
Published: |
Editorial Office of Journal of Sun Yat-sen University
2016-01-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
Subjects: | |
Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43569918/ |
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