Anti-ALK autoantibodies in patients with ALK-positive Non-Small Cell Lung Cancer (NSCLC): A monocentric experience

Anti-ALK autoantibodies in patients with ALK-positive Non-Small Cell Lung Cancer (NSCLC): A monocentric experience

Importance: Deregulation of anaplastic lymphoma kinase (ALK) occurs in 3–7% of advanced NSCLC mainly because of chromosomic rearrangements at the ALK locus. Next to its oncogenic function, ALK chimeric oncoprotein is a possible antigen for human immune system. The prognostic value of natural anti-AL...

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Main Authors: Claudia Parisi, José Carlos Benitez, Hélène Lecourt, Filippo Gustavo dall’Olio, Mihaela Aldea, Felix Blanc-Durand, Véronique Vergé, Cyril Quivoron, Charles Naltet, Pamela Abdayem, Pernelle Lavaud, Maria Rosa Ghigna, Luc Friboulet, Yohann Loriot, Stéphane De Botton, Vincent Ribrag, Andrea Ardizzoni, David Planchard, Jean-Charles Soria, Fabrice Barlesi, Benjamin Besse
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:The Journal of Liquid Biopsy
Subjects:
Anaplastic lymphoma kinase
ALK
Lung cancer
NSCLC
Circulating antibodies
Immunogenicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2950195424000298
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