Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24

Double vulnerability of active-NRF2 lung squamous cell carcinoma to NRF2 and TRIM24

Abstract Lung squamous cell cancer (LUSC) is associated with very poor survival due to the lack of specific treatments. A common genetic alteration in LUSC involves mutations in NFE2L2 (protein named NRF2) or its regulator, KEAP1, resulting in increased activity of the NRF2 transcription factor (TF)...

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Bibliographic Details
Main Authors: Miriam Sánchez-Ortega, Antonio Garrido, Lorena Sanz, Rafael Torres-Pérez, Carmen Hernandez, Alvaro Gutierrez-Uzquiza, Ming Sound Tsao, Ana Clara Carrera
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Cancer
Subjects:
LUSC treatment; NRF2
TRIM24
CRISPRa/dCas9
PI3Kα
Online Access:https://doi.org/10.1186/s12943-025-02401-y
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https://doi.org/10.1186/s12943-025-02401-y

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