Mortality-associated plasma proteome dynamics in a prospective multicentre sepsis cohortResearch in context

Mortality-associated plasma proteome dynamics in a prospective multicentre sepsis cohortResearch in context

Summary: Background: Sepsis remains a leading cause of mortality in intensive care units. Understanding the dynamics of the plasma proteome of patients with sepsis is critical for improving prognostic and therapeutic strategies. Methods: This prospective, multicentre observational cohort study incl...

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Main Authors: Lars Palmowski, Maike Weber, Malte Bayer, Yuxin Mi, Karin Schork, Martin Eisenacher, Hartmuth Nowak, Tim Rahmel, Lars Bergmann, Andrea Witowski, Björn Koos, Katharina Rump, Dominik Ziehe, Ulrich Limper, Dietrich Henzler, Stefan Felix Ehrentraut, Alexander Zarbock, Roman Fischer, Julian C. Knight, Michael Adamzik, Barbara Sitek, Thilo Bracht
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:EBioMedicine
Subjects:
Proteomics
Sepsis
Machine learning
Feature importance
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424005449
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