Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development

Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development

DNA gyrase is a member of the DNA topoisomerase protein family that catalyzes the conversion of different topological forms of DNA into one another. It is the sole enzyme that causes DNA to negatively supercoil. The enzyme is tetrameric with two GyrA (“A'') and two GyrB (“B'') su...

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Bibliographic Details
Main Authors: K. Rajakumari, K. Aravind, M. Balamugundhan, Manjunathan Jagadeesan, Ambiga Somasundaram, Parthiban Brindha Devi, Pasiyappazham Ramasamy
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
DNA gyrase
DNA replication
Quinolones
Coumarin
Drug discovery
Drug resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424001055
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