Adaptable gene‐specific dye bias correction for two‐channel DNA microarrays

Adaptable gene‐specific dye bias correction for two‐channel DNA microarrays

Abstract DNA microarray technology is a powerful tool for monitoring gene expression or for finding the location of DNA‐bound proteins. DNA microarrays can suffer from gene‐specific dye bias (GSDB), causing some probes to be affected more by the dye than by the sample. This results in large measurem...

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Bibliographic Details
Main Authors: Thanasis Margaritis, Philip Lijnzaad, Dik van Leenen, Diane Bouwmeester, Patrick Kemmeren, Sander R van Hooff, Frank CP Holstege
Format: Article
Language:English
Published: Springer Nature 2009-04-01
Series:Molecular Systems Biology
Subjects:
DNA microarrays
fluorescent dye labelling
mRNA expression profiling
normalization
two channel
Online Access:https://doi.org/10.1038/msb.2009.21
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https://doi.org/10.1038/msb.2009.21

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