C3 deficiency promotes pulmonary inflammation in AT1R-induced mouse model for systemic sclerosis

C3 deficiency promotes pulmonary inflammation in AT1R-induced mouse model for systemic sclerosis

IntroductionAutoantibody-mediated complement activation plays an essential role in a variety of autoimmune disorders. However, the role of complement in systemic sclerosis (SSc) remains largely unknown. In this study, we aimed to determine the role of complement C3 in the development of a recently d...

Full description

Saved in:

Bibliographic Details
Main Authors:	Junping Yin, Admar Verschoor, Xiaoyang Yue, Torsten Goldmann, Harald Heidecke, Gabriela Riemekasten, Frank Petersen, Xinhua Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Series:	Frontiers in Immunology
Subjects:	systemic sclerosis inflammation mouse model complement pulmonary inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1491324/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Role of Snake Venom Proteins in Inducing Inflammation Post-Envenomation: An Overview on Mechanistic Insights and Treatment Strategies
by: Sudharshan Rao, et al.
Published: (2024-12-01)

The effects of eight weeks’ yoga training on serum levels of IL-17 in women with multiple sclerosis
by: Seyed Mohsen Avandi, et al.
Published: (2019-06-01)

Prognostic Value of Systemic Inflammation, Nutritional Status and Sarcopenia in Patients With Amyotrophic Lateral Sclerosis
by: Yahui Zhu, et al.
Published: (2024-12-01)

Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis
by: J. Q. Alida Chen, et al.
Published: (2025-01-01)

The Janus-faced nature of complement in hemodialysis: interplay between complement, inflammation, and bioincompatibility unveiling a self-amplifying loop contributing to organ damage
by: Bernard Canaud, et al.
Published: (2024-12-01)

Chlorogenic Acid Alleviates Inflammation and Fibrosis in a Murine Model of Bleomycin-Induced Systemic Sclerosis: A Histological Analysis
by: Juan Manuel Velázquez-Enríquez, et al.
Published: (2024-11-01)

A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation
by: M. O. Ogundele
Published: (1998-01-01)

Complement activation in wasp venom-induced acute kidney injury
by: Rui Cheng, et al.
Published: (2024-12-01)

Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection
by: Liqiang Zhang, et al.
Published: (2023-08-01)

Unmasking culprits: novel analysis identifies complement factors as potential therapeutic targets to mitigate inflammation during children's heart surgery
by: Joel Bierer, et al.
Published: (2024-12-01)

Systemic Administration of a Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits and Neuroinflammation in Mice
by: Amit Kumar Madeshiya, et al.
Published: (2024-12-01)

Dorsoventral photobiomodulation therapy safely reduces inflammation and sensorimotor deficits in a mouse model of multiple sclerosis
by: Vincent Escarrat, et al.
Published: (2024-12-01)

Tet2-mediated clonal hematopoiesis modestly improves neurological deficits and is associated with inflammation resolution in the subacute phase of experimental stroke
by: Megan A. Evans, et al.
Published: (2024-12-01)

Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management
by: Bhargav Shreevatsa, et al.
Published: (2025-02-01)

Editorial: Aging, peripheral inflammation, and neurodegeneration
by: Caroline Haikal, et al.
Published: (2024-12-01)

Inflammatory and Nutritional Markers as Indicators for Diagnosing and Assessing Disease Activity in MS and NMOSD
by: Li X, et al.
Published: (2024-11-01)

Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis
by: Madalena B. C. Simões-Abade, et al.
Published: (2024-12-01)

Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis
by: Veronika Sebestyén, et al.
Published: (2025-01-01)

The pivotal role of osteopontin in UV-induced skin inflammation in a mouse model
by: Haesoo Kim, et al.
Published: (2024-11-01)

Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system
by: Su-Min Park, et al.
Published: (2025-01-01)

THE PPARG RECEPTOR AGONIST PIOGLITAZONE REDUCES PULMONARY FIBROSIS INDUCED BY BLEOMYCIN ADMINISTRATION IN MICE
by: A.V. Kabaliei, et al.
Published: (2024-12-01)

The role of interleukin-17 in inflammation-related cancers
by: Xingru Zhang, et al.
Published: (2025-01-01)

Anaemia of inflammation in sickle cell disease: A review of aetiopathogenesis, management, and prevention of sterile and septic inflammation in patients with sickle cell disease
by: Ahmed SG, et al.
Published: (2025-01-01)

CycloZ Suppresses TLR4-Driven Inflammation to Reduce Asthma-Like Responses in HDM-Exposed Mouse Models
by: Dohyun Lee, et al.
Published: (2024-12-01)

Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients
by: Amela DERVISEVIC, et al.
Published: (2024-09-01)

Relevance of diet in schizophrenia: a review focusing on prenatal nutritional deficiency, obesity, oxidative stress and inflammation
by: Viorica Rarinca, et al.
Published: (2024-12-01)

Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study
by: Esra Cataltepe, et al.
Published: (2025-01-01)

C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment
by: Jiaojiao Zhu, et al.
Published: (2025-01-01)

Preliminary Diagnosis and Characterization of a Spontaneous Immature Testicular Teratoma in an Interferon Receptor-Deficient Mouse Model
by: ZHAO He, et al.
Published: (2024-12-01)

Histone demethylases in autophagy and inflammation
by: Yaoyao Ma, et al.
Published: (2025-01-01)

The Predictive and Prognostic Value of the Systemic Immune-Inflammation Index for Congestive Heart Failure
by: Zhihao Zheng, et al.
Published: (2024-11-01)

Impact of T-2 toxin on intestinal inflammation and transcriptional regulation of inflammatory response in mouse macrophages
by: Xinghui Yang, et al.
Published: (2024-12-01)

The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis
by: Femke Van Gaever, et al.
Published: (2024-12-01)

Relationship between systemic immune-inflammation index and depression among individuals with and without cardiovascular disease
by: Dan Liu, et al.
Published: (2025-01-01)

Inflammation, immunity, and vaccines
by: R. Gong, et al.
Published: (2024-09-01)

Inflammatory role of S100A8/A9 in the central nervous system non-neoplastic diseases
by: Qi Tian, et al.
Published: (2024-11-01)

Interactions between vitamin D deficiency and inflammation on diabetes risk: data from 336,500 UK Biobank adults
by: Jatupol Kositsawat, et al.
Published: (2025-02-01)

New inflammatory markers associated with disease activity in rheumatoid arthritis: pan-immune-inflammation value, systemic immune-inflammation index, and systemic inflammation response index
by: İpek Okutan, et al.
Published: (2024-12-01)

Adalimumab Treatment Effects on Inflammation and Adipose Tissue Mitochondrial Respiration in Hidradenitis Suppurativa
by: Ronni Eg Sahl, et al.
Published: (2024-11-01)

Corrigendum: The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis
by: Femke Van Gaever, et al.
Published: (2025-02-01)