C3 deficiency promotes pulmonary inflammation in AT1R-induced mouse model for systemic sclerosis

C3 deficiency promotes pulmonary inflammation in AT1R-induced mouse model for systemic sclerosis

IntroductionAutoantibody-mediated complement activation plays an essential role in a variety of autoimmune disorders. However, the role of complement in systemic sclerosis (SSc) remains largely unknown. In this study, we aimed to determine the role of complement C3 in the development of a recently d...

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Bibliographic Details
Main Authors: Junping Yin, Admar Verschoor, Xiaoyang Yue, Torsten Goldmann, Harald Heidecke, Gabriela Riemekasten, Frank Petersen, Xinhua Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis
inflammation
mouse model
complement
pulmonary inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1491324/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1491324/full

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