Experimental Models of Type 2 Diabetes Mellitus Induced by Combining Hyperlipidemic Diet (HFD) and Streptozotocin Administration in Rats: An Integrative Review

Experimental Models of Type 2 Diabetes Mellitus Induced by Combining Hyperlipidemic Diet (HFD) and Streptozotocin Administration in Rats: An Integrative Review

Type 2 diabetes mellitus (DM2) is a metabolic disorder characterized by chronic hyperglycemia associated with low insulin production and/or insulin resistance. A high-fat diet (HFD) combined with a low dose of streptozotocin (STZ) in an animal model produces a disease that mimics type 2 diabetes mel...

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Main Authors: Ana Karolinne da Silva Brito, Ana Victória da Silva Mendes, Boris Timah Acha, Amanda Suellenn da Silva Santos Oliveira, Joyce Lopes Macedo, Akemi Suzuki Cruzio, Maria das Graças Prianti, Raquel Rodrigues de Abreu, Massimo Lucarini, Alessandra Durazzo, Maria do Carmo de Carvalho e Martins, Daniel Dias Rufino Arcanjo
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
animal model
type 2 diabetes mellitus
high-fat diet
streptozotocin
Online Access:https://www.mdpi.com/2227-9059/13/5/1158
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