Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue

Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue

Abstract Introduction Vascular contributions to cognitive impairment and dementia (VCID) are a leading cause of dementia. An underappreciated, modifiable risk factor for VCID is hyperhomocysteinemia (HHcy), defined by elevated levels of plasma homocysteine, most often due to impaired B vitamin absor...

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Main Authors: Erica M. Weekman, Zach Winder, Colin B. Rogers, Erin L. Abner, Tiffany L. Sudduth, Ela Patel, Adam J. Dugan, Shuling X. Fister, Brandi Wasek, Peter T. Nelson, Gregory A. Jicha, Teodoro Bottiglieri, David W. Fardo, Donna M. Wilcock
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
astrocytes
atherosclerosis
hyperhomocysteinemia
microglia
microhemorrhages
Online Access:https://doi.org/10.1002/trc2.12368
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https://doi.org/10.1002/trc2.12368

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