A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicityResearch in context

A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicityResearch in context

Summary: Background: Global dissemination of SARS-CoV-2 Omicron sublineages has provided a sufficient opportunity for natural selection, thus enabling beneficial mutations to emerge. Characterisation of these mutations uncovers the underlying machinery responsible for the fast transmission of Omicr...

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Main Authors: Yuhan Li, Xianwen Zhang, Wanbo Tai, Xinyu Zhuang, Huicheng Shi, Shumin Liao, Xinyang Yu, Rui Mei, Xingzhao Chen, Yanhong Huang, Yubin Liu, Jianying Liu, Yang Liu, Yibin Zhu, Penghua Wang, Mingyao Tian, Guocan Yu, Liang Li, Gong Cheng
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
High-frequency mutations
Spike variants
Virus entry
Virus-like particle mRNA vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424004730
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