Identification of a Patient Suitable for CAR-T Cell Therapy in the Outpatient Setting: A Vodcast and Case Example
Abstract Chimeric antigen receptor T cell (CAR-T) therapies targeting the CD19 antigen have been associated with high and durable response rates in patients with diffuse large B cell lymphoma (DLBCL). CAR-T cell therapies are commonly administered in the inpatient setting due to the average onset of...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-04-01
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| Series: | Oncology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40487-024-00272-9 |
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| author | Ronan Foley John Kuruvilla |
| author_facet | Ronan Foley John Kuruvilla |
| author_sort | Ronan Foley |
| collection | DOAJ |
| description | Abstract Chimeric antigen receptor T cell (CAR-T) therapies targeting the CD19 antigen have been associated with high and durable response rates in patients with diffuse large B cell lymphoma (DLBCL). CAR-T cell therapies are commonly administered in the inpatient setting due to the average onset of cytokine release syndrome within the first 3 days post infusion, but there has been growing interest in delivering CAR-T cell therapies in the outpatient setting to overcome frequent hospital bed shortages and the high cost of inpatient care. Although this approach could improve access whilst catering to patient preference, it requires a multidisciplinary approach as well as careful patient selection. Herein, Dr. Foley and Dr. Kuruvilla discuss the case of a patient presenting with the ideal profile for CAR-T cell therapy referral whilst also determining the key attributes for eligibility from a clinician’s perspective. Solutions for successful outpatient management include proper education, caregiver support, and early referral to ensure a timely infusion. In conclusion, outpatient administration of CAR-T cell therapy in patients with DLBCLs should be assessed on a case-by-case basis. A vodcast feature is available for this article. |
| format | Article |
| id | doaj-art-3049620d8bad476589d264379dd4940d |
| institution | Kabale University |
| issn | 2366-1070 2366-1089 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Oncology and Therapy |
| spelling | doaj-art-3049620d8bad476589d264379dd4940d2025-01-12T12:11:48ZengAdis, Springer HealthcareOncology and Therapy2366-10702366-10892024-04-0112223924510.1007/s40487-024-00272-9Identification of a Patient Suitable for CAR-T Cell Therapy in the Outpatient Setting: A Vodcast and Case ExampleRonan Foley0John Kuruvilla1Juravinski Hospital and Cancer CentrePrincess Margaret Cancer CentreAbstract Chimeric antigen receptor T cell (CAR-T) therapies targeting the CD19 antigen have been associated with high and durable response rates in patients with diffuse large B cell lymphoma (DLBCL). CAR-T cell therapies are commonly administered in the inpatient setting due to the average onset of cytokine release syndrome within the first 3 days post infusion, but there has been growing interest in delivering CAR-T cell therapies in the outpatient setting to overcome frequent hospital bed shortages and the high cost of inpatient care. Although this approach could improve access whilst catering to patient preference, it requires a multidisciplinary approach as well as careful patient selection. Herein, Dr. Foley and Dr. Kuruvilla discuss the case of a patient presenting with the ideal profile for CAR-T cell therapy referral whilst also determining the key attributes for eligibility from a clinician’s perspective. Solutions for successful outpatient management include proper education, caregiver support, and early referral to ensure a timely infusion. In conclusion, outpatient administration of CAR-T cell therapy in patients with DLBCLs should be assessed on a case-by-case basis. A vodcast feature is available for this article.https://doi.org/10.1007/s40487-024-00272-9CAR-T therapyMultidisciplinary approachOutpatientPatient casePatient selection |
| spellingShingle | Ronan Foley John Kuruvilla Identification of a Patient Suitable for CAR-T Cell Therapy in the Outpatient Setting: A Vodcast and Case Example Oncology and Therapy CAR-T therapy Multidisciplinary approach Outpatient Patient case Patient selection |
| title | Identification of a Patient Suitable for CAR-T Cell Therapy in the Outpatient Setting: A Vodcast and Case Example |
| title_full | Identification of a Patient Suitable for CAR-T Cell Therapy in the Outpatient Setting: A Vodcast and Case Example |
| title_fullStr | Identification of a Patient Suitable for CAR-T Cell Therapy in the Outpatient Setting: A Vodcast and Case Example |
| title_full_unstemmed | Identification of a Patient Suitable for CAR-T Cell Therapy in the Outpatient Setting: A Vodcast and Case Example |
| title_short | Identification of a Patient Suitable for CAR-T Cell Therapy in the Outpatient Setting: A Vodcast and Case Example |
| title_sort | identification of a patient suitable for car t cell therapy in the outpatient setting a vodcast and case example |
| topic | CAR-T therapy Multidisciplinary approach Outpatient Patient case Patient selection |
| url | https://doi.org/10.1007/s40487-024-00272-9 |
| work_keys_str_mv | AT ronanfoley identificationofapatientsuitableforcartcelltherapyintheoutpatientsettingavodcastandcaseexample AT johnkuruvilla identificationofapatientsuitableforcartcelltherapyintheoutpatientsettingavodcastandcaseexample |