The impact of 9-azaglycophymine and phenylguanidine derivatives on the proliferation of various breast cancer cell lines in vitro and in vivo

The impact of 9-azaglycophymine and phenylguanidine derivatives on the proliferation of various breast cancer cell lines in vitro and in vivo

Abstract Quinazolinones, particularly 9-azaglycophymines, and closely related derivatives and precursors were tested in vitro against various breast cancer cell lines representing the major types of breast tumors. Among the 49 compounds tested, azaglycophymine derivative 19 with an electron-withdraw...

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Main Authors: Ibrahim Morgan, Robert Rennert, Robert Berger, Sanja Jelača, Danijela Maksimović-Ivanić, Duško Dunđerović, Sanja Mijatović, Goran N. Kaluđerović, Ludger A. Wessjohann
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Quinazoline
Quinazolinone
Anticancer
Apoptosis
Breast cancer
Structure-activity-relationship
Online Access:https://doi.org/10.1038/s41598-024-71624-8
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https://doi.org/10.1038/s41598-024-71624-8

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