From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy

From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy

Abstract In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approval of six therapeutic products for haematological malignancies. Recently, the therapeutic potential of this therapy has also been demonstrated in non-tumoral diseases. C...

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Bibliographic Details
Main Authors: E. Pinto, L. Lione, M. Compagnone, M. Paccagnella, E. Salvatori, M. Greco, V. Frezza, E. Marra, L. Aurisicchio, G. Roscilli, A. Conforti
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
CAR T cell
Manufacturing
T cell engineering
Online Access:https://doi.org/10.1186/s12967-024-06052-3
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