Evaluation of the antibacterial and efflux inhibitory activity of trans-cinnamic acid in Staphylococcus aureus: Experimental assays and in silico modeling

Evaluation of the antibacterial and efflux inhibitory activity of trans-cinnamic acid in Staphylococcus aureus: Experimental assays and in silico modeling

Background: Staphylococcus aureus develops bacterial resistance using membrane transport systems that perform the active efflux of antimicrobial agents, allowing its survival and growth. Objective: This study evaluated the antibacterial activity of trans-cinnamic acid and its ability to modify the a...

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Main Authors: Nair Silva Macêdo, Zildene de Sousa Silveira, Débora Menezes Dantas, Cristina Rodrigues dos Santos Barbosa, Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, Thaís Ferreira da Silva, Márcia Machado Marinho, Matheus Nunes da Rocha, Henrique Douglas Melo Coutinho, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Francisco Assis Bezerra da Cunha
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Phytomedicine Plus
Subjects:
Multidrug-resistant microorganisms
Phenolic acids
Combination therapy
Efflux inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2667031325000880
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