The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer’s mouse model

The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer’s mouse model

IntroductionAlzheimer’s disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and anxiety, and can reduce dementia risk, it is associat...

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Bibliographic Details
Main Authors: M. R. Schwabe, A. W. Fleischer, R. K. Kuehn, S. Chaudhury, J. M. York, D. S. Sem, W. A. Donaldson, M. J. LaDu, K. M. Frick
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
estrogen receptor beta (ERβ)
apolipoprotein E
object recognition
object placement
hot flash
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1477045/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2024.1477045/full

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