TAS2R38 genotype and CRS severity in children with cystic fibrosis
Background: Cystic fibrosis is a heterogeneous disease whose severity and symptoms largely depend on the functional impact of mutations in the cystic fibrosis transmembrane conductance regulator gene. Other genes may also modulate the clinical manifestations and complications associated with cystic...
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025000969 |
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| author | Elena Cantone Antonella Tosco Angela Sepe Valeria Raia Rossella Negri Alice Castaldo Chiara Cimbalo Paolo Pezzella Mario Brandon Russo Giusi Grimaldi Claudio Di Nola Luigi Greco |
| author_facet | Elena Cantone Antonella Tosco Angela Sepe Valeria Raia Rossella Negri Alice Castaldo Chiara Cimbalo Paolo Pezzella Mario Brandon Russo Giusi Grimaldi Claudio Di Nola Luigi Greco |
| author_sort | Elena Cantone |
| collection | DOAJ |
| description | Background: Cystic fibrosis is a heterogeneous disease whose severity and symptoms largely depend on the functional impact of mutations in the cystic fibrosis transmembrane conductance regulator gene. Other genes may also modulate the clinical manifestations and complications associated with cystic fibrosis. Genetic variants of the bitter taste receptor TAS2R38 have been shown to contribute to the susceptibility and severity of chronic rhinosinusitis. This study aims to elucidate the role of TAS2R38 as a novel modifier gene influencing sinonasal disease severity and pulmonary Pseudomonas Aeruginosa colonization in children with cystic fibrosis. Methods: This retrospective observational case-control study evaluated sinus clinical features, quality of life, and the occurrence of Pseudomonas Aeruginosa pulmonary colonization in 69 children with cystic fibrosis. Propylthiouracil testing and TAS2R38 genotyping were performed to characterize patients based on receptor functionality. Results: The non-taster genetic variant of bitter taste receptor TAS2R38 was associated with greater severity of chronic rhinosinusitis, as measured by endoscopic and radiological scores, compared to the taster variant (p = 0.031 and p = 0.03, respectively). Furthermore, an inverse correlation was observed between the age at first Pseudomonas Aeruginosa infection and chronic rhinosinusitis severity assessed by endoscopic score (r = −0.3388, p = 0.0302). Conclusions: The findings highlight the role of TAS2R38 as a potential genetic modifier influencing the severity of chronic rhinosinusitis in children with cystic fibrosis. The clinical implications include the potential development of T2R38-targeted topical therapies and the use of taste testing or genotyping to predict susceptibility to infection. In addition, these results may pave the way for novel, tailored therapeutic approaches in the era of precision medicine. |
| format | Article |
| id | doaj-art-2f9ffd6272514acca9823b1122123793 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-2f9ffd6272514acca9823b11221237932025-01-17T04:51:57ZengElsevierHeliyon2405-84402025-01-01111e41716TAS2R38 genotype and CRS severity in children with cystic fibrosisElena Cantone0Antonella Tosco1Angela Sepe2Valeria Raia3Rossella Negri4Alice Castaldo5Chiara Cimbalo6Paolo Pezzella7Mario Brandon Russo8Giusi Grimaldi9Claudio Di Nola10Luigi Greco11Department of Neuroscience, Reproductive and Dentistry Science, ENT section, “Federico II University of Naples”, Naples, Italy; Corresponding author. Via Pansini, 5, Naples, Italy.Paediatric Unit, Department of Maternal and Child Health, Cystic Fibrosis Regional Reference Center, A.O.U. Federico II, Naples, ItalyPaediatric Unit, Department of Maternal and Child Health, Cystic Fibrosis Regional Reference Center, A.O.U. Federico II, Naples, ItalyPaediatric Unit, Department of Maternal and Child Health, Cystic Fibrosis Regional Reference Center, A.O.U. Federico II, Naples, ItalyPaediatric Unit, Department of Maternal and Child Health, Cystic Fibrosis Regional Reference Center, A.O.U. Federico II, Naples, ItalyPaediatric Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, ItalyPaediatric Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive and Dentistry Science, ENT section, “Federico II University of Naples”, Naples, ItalyDepartment of Engineering, University of Campania “Luigi Vanvitelli”, Aversa, ItalyDepartment of Neuroscience, Reproductive and Dentistry Science, ENT section, “Federico II University of Naples”, Naples, ItalyDepartment of Neuroscience, Reproductive and Dentistry Science, ENT section, “Federico II University of Naples”, Naples, ItalyPaediatric Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, ItalyBackground: Cystic fibrosis is a heterogeneous disease whose severity and symptoms largely depend on the functional impact of mutations in the cystic fibrosis transmembrane conductance regulator gene. Other genes may also modulate the clinical manifestations and complications associated with cystic fibrosis. Genetic variants of the bitter taste receptor TAS2R38 have been shown to contribute to the susceptibility and severity of chronic rhinosinusitis. This study aims to elucidate the role of TAS2R38 as a novel modifier gene influencing sinonasal disease severity and pulmonary Pseudomonas Aeruginosa colonization in children with cystic fibrosis. Methods: This retrospective observational case-control study evaluated sinus clinical features, quality of life, and the occurrence of Pseudomonas Aeruginosa pulmonary colonization in 69 children with cystic fibrosis. Propylthiouracil testing and TAS2R38 genotyping were performed to characterize patients based on receptor functionality. Results: The non-taster genetic variant of bitter taste receptor TAS2R38 was associated with greater severity of chronic rhinosinusitis, as measured by endoscopic and radiological scores, compared to the taster variant (p = 0.031 and p = 0.03, respectively). Furthermore, an inverse correlation was observed between the age at first Pseudomonas Aeruginosa infection and chronic rhinosinusitis severity assessed by endoscopic score (r = −0.3388, p = 0.0302). Conclusions: The findings highlight the role of TAS2R38 as a potential genetic modifier influencing the severity of chronic rhinosinusitis in children with cystic fibrosis. The clinical implications include the potential development of T2R38-targeted topical therapies and the use of taste testing or genotyping to predict susceptibility to infection. In addition, these results may pave the way for novel, tailored therapeutic approaches in the era of precision medicine.http://www.sciencedirect.com/science/article/pii/S2405844025000969Cystic fibrosisChronic rhinosinusitisBitter receptorTAS2R38Pseudomonas aeruginosa |
| spellingShingle | Elena Cantone Antonella Tosco Angela Sepe Valeria Raia Rossella Negri Alice Castaldo Chiara Cimbalo Paolo Pezzella Mario Brandon Russo Giusi Grimaldi Claudio Di Nola Luigi Greco TAS2R38 genotype and CRS severity in children with cystic fibrosis Heliyon Cystic fibrosis Chronic rhinosinusitis Bitter receptor TAS2R38 Pseudomonas aeruginosa |
| title | TAS2R38 genotype and CRS severity in children with cystic fibrosis |
| title_full | TAS2R38 genotype and CRS severity in children with cystic fibrosis |
| title_fullStr | TAS2R38 genotype and CRS severity in children with cystic fibrosis |
| title_full_unstemmed | TAS2R38 genotype and CRS severity in children with cystic fibrosis |
| title_short | TAS2R38 genotype and CRS severity in children with cystic fibrosis |
| title_sort | tas2r38 genotype and crs severity in children with cystic fibrosis |
| topic | Cystic fibrosis Chronic rhinosinusitis Bitter receptor TAS2R38 Pseudomonas aeruginosa |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025000969 |
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