HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1

HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1

Abstract Helper-component proteinase (HC-Pro), encoded by potyviruses, function as viral suppressors of RNA silencing (VSRs). Despite their conserved role, HC-Pros share approximately 40% similarity, implying potential differences in VSR efficiency, particularly in their ability to inhibit HEN1 meth...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhao-Jun Pan, Wei-Lun Wei, Phuong-Anh Tran, Ru-Ying Fang, Thanh Ha Pham, John L. Bowman, Chao-Tzu Chung, Bing-Nan Shen, Ju-Ting Yang, Han-Han Chang, Wann-Neng Jane, Chiung-Hsiang Cheng, Chia-Chi Wang, Hsin-Yi Wu, Syuan-Fei Hong, Qian-Wen Shang, Sin-Fen Hu, Pin-Chun Lin, Fu-Hui Wu, Choun-Sea Lin, Yu-Ling Hung, Tang-Long Shen, Shih-Shun Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56320-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-025-56320-z

Similar Items