Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III regionResearch in context

Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III regionResearch in context

Summary: Background: This study aims to confirm the associations of air pollution with ulcerative colitis (UC) and Crohn's disease (CD); to explore interactions with genetics and lifestyle; and to characterize potential epigenetic mechanisms. Methods: We identified over 450,000 individuals fro...

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Main Authors: Jie Chen, Han Zhang, Tian Fu, Jianhui Zhao, Jan Krzysztof Nowak, Rahul Kalla, Judith Wellens, Shuai Yuan, Alexandra Noble, Nicholas T. Ventham, Malcolm G. Dunlop, Jonas Halfvarson, Ren Mao, Evropi Theodoratou, Jack Satsangi, Xue Li
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:EBioMedicine
Subjects:
Inflammatory bowel disease
Air pollution
DNA methylation
Mendelian randomization
MHC III region
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424004791
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