Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway

Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway

Abstract Background The imbalance of macrophage polarization plays a pivotal role in the progression of rheumatoid arthritis (RA). Reprogramming macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype is considered a promising therapeutic strategy. Methods To address...

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Bibliographic Details
Main Authors: Yang Yu, Liang Kong, Rui-bo Guo, Ya-ni Zhang, Shu-tong Li, Feng-yuan Zhang, Xin Wang, Yang Liu, Xiu-Ying Li, Xue-tao Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Rheumatoid arthritis
Panax Notoginseng polysaccharide
Micelles
Macrophage polarization
JAK2-STAT3
Online Access:https://doi.org/10.1186/s12951-025-03576-8
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https://doi.org/10.1186/s12951-025-03576-8

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