LOX-induced tubulointerstitial fibrosis via the TGF-β/LOX/Snail axis in diabetic mice

LOX-induced tubulointerstitial fibrosis via the TGF-β/LOX/Snail axis in diabetic mice

Abstract Background The partial epithelial-mesenchymal transition (EMT) is emerging as a significant mechanism in diabetic nephropathy (DN). LOX is a copper amine oxidase conventionally thought to act by crosslinking collagen. However, the role of LOX in partial EMT and fibrotic progression in diabe...

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Bibliographic Details
Main Authors:	Yicheng Lu, Heyangzi Li, Mohan Chen, Yicheng Lin, Xiaoming Zhang
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Journal of Translational Medicine
Subjects:	Lysyl oxidase Single-nuclei RNA sequencing Diabetic nephropathy Partial epithelial-mesenchymal transition Tubulointerstitial fibrosis
Online Access:	https://doi.org/10.1186/s12967-024-06056-z
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