Accelerating Effects of Poloxamer and Its Structural Analogs on the Crystallization of Nitrendipine Polymorphs

Accelerating Effects of Poloxamer and Its Structural Analogs on the Crystallization of Nitrendipine Polymorphs

<b>Background:</b> Surfactants can be added into polymer–amorphous drug systems to further enhance solubility. However, this may cause amorphous drugs to become physically unstable, and the inherent mechanism at play here is not fully understood. <b>Methods:</b> We explored t...

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Main Authors: Jie Zhang, Qiusheng Yang, Meixia Xu, Xinqiang Tan, Xucong Peng, Ziqing Yang, Kang Li, Jia Yang, Jie Chen, Xuan Xun, Saijun Xiao, Lingjie Zhou, Minzhuo Liu, Zhihong Zeng
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
amorphous drug
poloxamer
crystallization
nitrendipine
Online Access:https://www.mdpi.com/1424-8247/18/7/1000
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https://www.mdpi.com/1424-8247/18/7/1000

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