Loss of Carbamoyl Phosphate Synthetase 1 Potentiates Hepatocellular Carcinoma Metastasis by Reducing Aspartate Level

Loss of Carbamoyl Phosphate Synthetase 1 Potentiates Hepatocellular Carcinoma Metastasis by Reducing Aspartate Level

Abstract Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Numerous studies have shown that metabolic reprogramming is crucial for the development of HCC. Carbamoyl phosphate synthase 1 (CPS1), a rate‐limiting enzyme in urea cycle, is an abundant protein in normal hepatocyt...

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Main Authors: Siyuan Chen, Qin Tang, Manqiu Hu, Sijie Song, Xiaohong Wu, You Zhou, Zihan Yang, Siqi Liao, Li Zhou, Qingliang Wang, Hongtao Liu, Mengsu Yang, Zhe‐Sheng Chen, Wei Zhao, Song He, Zhihang Zhou
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
aspartate
CPS1
m6A
metastasis
PC‐PLC
Online Access:https://doi.org/10.1002/advs.202402703
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https://doi.org/10.1002/advs.202402703

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