General medical comorbidities in psychotic disorders in the Finnish SUPER study
Abstract Schizophrenia (SZ), schizoaffective disorder (SZA), bipolar disorder (BD), and psychotic depression (PD) are associated with premature death due to preventable general medical comorbidities (GMCs). The interaction between psychosis, risk factors, and GMCs is complex and should be elucidated...
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Nature Portfolio
2024-12-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-024-00546-1 |
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| author | Johan Ahti Tuula Kieseppä Willehard Haaki Jaana Suvisaari Solja Niemelä Kimmo Suokas Minna Holm Asko Wegelius Olli Kampman Markku Lähteenvuo Tiina Paunio Jari Tiihonen Jarmo Hietala Erkki Isometsä |
| author_facet | Johan Ahti Tuula Kieseppä Willehard Haaki Jaana Suvisaari Solja Niemelä Kimmo Suokas Minna Holm Asko Wegelius Olli Kampman Markku Lähteenvuo Tiina Paunio Jari Tiihonen Jarmo Hietala Erkki Isometsä |
| author_sort | Johan Ahti |
| collection | DOAJ |
| description | Abstract Schizophrenia (SZ), schizoaffective disorder (SZA), bipolar disorder (BD), and psychotic depression (PD) are associated with premature death due to preventable general medical comorbidities (GMCs). The interaction between psychosis, risk factors, and GMCs is complex and should be elucidated. More research particularly among those with SZA or PD is warranted. We evaluated the association between registry-based psychotic disorders and GMC diagnoses in a large national sample of participants with different psychotic disorders. In addition, we examined whether body mass index (BMI) and smoking as risk factors for GMCs explain differences between diagnostic groups. This was a cross-sectional study of a clinical population of participants (n = 10,417) in the Finnish SUPER study. Registry-based diagnoses of psychotic disorders and hypertension, diabetes, chronic obstructive pulmonary disease (COPD), cancers, ischemic heart disease, and liver disorders were obtained. Participants’ BMI and self-reported smoking were recorded. Total effect of diagnostic category adjusted for age and sex as well as direct effect including known risk factors was calculated using logistic regression. Regardless of diagnostic category, participants had high BMI (average 30.3 kg/m2), and current smoking was common (42.4%). Diabetes and COPD were more common in SZ than in other diagnostic categories. The differences between psychotic disorders were not explained by obesity or smoking status only. Obesity and smoking were prevalent in all diagnostic categories of psychotic disorders, and continued efforts at prevention are warranted. Additional differences in GMC prevalence exist between psychotic disorders that are not explained by obesity and smoking. |
| format | Article |
| id | doaj-art-2e76445d2ffe41dab2da52f8ee19fe20 |
| institution | Kabale University |
| issn | 2754-6993 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj-art-2e76445d2ffe41dab2da52f8ee19fe202025-01-05T12:33:25ZengNature PortfolioSchizophrenia2754-69932024-12-011011810.1038/s41537-024-00546-1General medical comorbidities in psychotic disorders in the Finnish SUPER studyJohan Ahti0Tuula Kieseppä1Willehard Haaki2Jaana Suvisaari3Solja Niemelä4Kimmo Suokas5Minna Holm6Asko Wegelius7Olli Kampman8Markku Lähteenvuo9Tiina Paunio10Jari Tiihonen11Jarmo Hietala12Erkki Isometsä13Department of Psychiatry, University of Helsinki and Helsinki University HospitalHospital District of Helsinki and UusimaaDepartment of Psychiatry, University of Turku, Turku, Finland and Department of Psychiatry, Turku University HospitalMental Health Team, Finnish Institute for Health and WelfareDepartment of Psychiatry, University of Turku, Turku, Finland and Addiction Psychiatry Unit, Department of Psychiatry, Hospital District of South-WestTampere University Hospital, Tampere, Finland and Department of Psychiatry, Pirkanmaa Hospital DistrictMental Health Unit, Finnish Institute for Health and WelfareDepartment of Psychiatry, University of Helsinki and Helsinki University HospitalDepartment of Clinical Sciences, Psychiatry, Umeå UniversityDepartment of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern FinlandSleepWell Research Program and Department of Psychiatry, Faculty of Medicine, University of Helsinki and Helsinki University Hospital; Mental Health Unit, Finnish Institute for Health and WelfareDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden and Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern FinlandDepartment of Psychiatry, Turku University HospitalDepartment of Psychiatry, University of Helsinki and Helsinki University HospitalAbstract Schizophrenia (SZ), schizoaffective disorder (SZA), bipolar disorder (BD), and psychotic depression (PD) are associated with premature death due to preventable general medical comorbidities (GMCs). The interaction between psychosis, risk factors, and GMCs is complex and should be elucidated. More research particularly among those with SZA or PD is warranted. We evaluated the association between registry-based psychotic disorders and GMC diagnoses in a large national sample of participants with different psychotic disorders. In addition, we examined whether body mass index (BMI) and smoking as risk factors for GMCs explain differences between diagnostic groups. This was a cross-sectional study of a clinical population of participants (n = 10,417) in the Finnish SUPER study. Registry-based diagnoses of psychotic disorders and hypertension, diabetes, chronic obstructive pulmonary disease (COPD), cancers, ischemic heart disease, and liver disorders were obtained. Participants’ BMI and self-reported smoking were recorded. Total effect of diagnostic category adjusted for age and sex as well as direct effect including known risk factors was calculated using logistic regression. Regardless of diagnostic category, participants had high BMI (average 30.3 kg/m2), and current smoking was common (42.4%). Diabetes and COPD were more common in SZ than in other diagnostic categories. The differences between psychotic disorders were not explained by obesity or smoking status only. Obesity and smoking were prevalent in all diagnostic categories of psychotic disorders, and continued efforts at prevention are warranted. Additional differences in GMC prevalence exist between psychotic disorders that are not explained by obesity and smoking.https://doi.org/10.1038/s41537-024-00546-1 |
| spellingShingle | Johan Ahti Tuula Kieseppä Willehard Haaki Jaana Suvisaari Solja Niemelä Kimmo Suokas Minna Holm Asko Wegelius Olli Kampman Markku Lähteenvuo Tiina Paunio Jari Tiihonen Jarmo Hietala Erkki Isometsä General medical comorbidities in psychotic disorders in the Finnish SUPER study Schizophrenia |
| title | General medical comorbidities in psychotic disorders in the Finnish SUPER study |
| title_full | General medical comorbidities in psychotic disorders in the Finnish SUPER study |
| title_fullStr | General medical comorbidities in psychotic disorders in the Finnish SUPER study |
| title_full_unstemmed | General medical comorbidities in psychotic disorders in the Finnish SUPER study |
| title_short | General medical comorbidities in psychotic disorders in the Finnish SUPER study |
| title_sort | general medical comorbidities in psychotic disorders in the finnish super study |
| url | https://doi.org/10.1038/s41537-024-00546-1 |
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