Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidity

Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidity

Coronaviruses cause severe human viral diseases including SARS, MERS and COVID-19. Most recently SARS-CoV-2 virus (causing COVID-19) has led to a pandemic with no successful therapeutics. The SARS-CoV-2 infection relies on trimeric spike (S) proteins to facilitate virus entry into host cells by bind...

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Bibliographic Details
Main Authors: Jianbo Dong, Betty Huang, Zhejun Jia, Bo Wang, Sachith Gallolu Kankanamalage, Allison Titong, Yue Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
COVID-19
bi-specific antibody
tri-specific antibody
llama antibody
humanized antibody
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1768806
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https://www.tandfonline.com/doi/10.1080/22221751.2020.1768806

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