Engineering extracellular vesicles to transiently permeabilize the blood–brain barrier

Engineering extracellular vesicles to transiently permeabilize the blood–brain barrier

Abstract Background Drug delivery to the brain is challenging due to the restrict permeability of the blood brain barrier (BBB). Recent studies indicate that BBB permeability increases over time during physiological aging likely due to factors (including extracellular vesicles (EVs)) that exist in t...

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Bibliographic Details
Main Authors: Francesca Tomatis, Susana Rosa, Susana Simões, Marta Barão, Carlos Jesus, João Novo, Emanuel Barth, Manja Marz, Lino Ferreira
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Extracellular vesicles
Modulation
MicroRNA
Blood–brain barrier
Microfluidic system
Claudin 5
Online Access:https://doi.org/10.1186/s12951-024-03019-w
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https://doi.org/10.1186/s12951-024-03019-w

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