PAX6-dependent differentiation landscape of ocular surface epithelium via single-cell RNA sequencing in hiPSC-derived ocular developmental organoid

PAX6-dependent differentiation landscape of ocular surface epithelium via single-cell RNA sequencing in hiPSC-derived ocular developmental organoid

Abstract During eye development, surface ectoderm cells that express PAX6 differentiate into corneal, limbal and conjunctival epithelia. However, several aspects of this differentiation process -- such as the developmental origin of the limbal epithelium and the mechanisms that underlie PAX6-mediate...

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Main Authors: Rei Kamuro, Masahito Yoshihara, Susumu Hara, Takahiro Nemoto, Laura Howard, Ai Honda, Ayano Yamamoto, Toru Takigawa, Susumu Sakimoto, Koichi Baba, Andrew J. Quantock, Kohji Nishida
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08643-2
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https://doi.org/10.1038/s42003-025-08643-2

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