Tissue-specific roles of de novo DNA methyltransferases

Tissue-specific roles of de novo DNA methyltransferases

Abstract DNA methylation, catalyzed by DNA methyltransferases (DNMT), plays pivotal role in regulating embryonic development, gene expression, adaption to environmental stress, and maintaining genome integrity. DNMT family consists of DNMT1, DNMT3A, DNMT3B, and the enzymatically inactive DNMT3L. DNM...

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Bibliographic Details
Main Authors: Dániel Márton Tóth, Flóra Szeri, Mária Ashaber, Muhyiddeen Muazu, Lóránt Székvölgyi, Tamás Arányi
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
De novo methyltransferase
Dnmt3a
Dnmt3b
Knockout
Cre recombinase
Online Access:https://doi.org/10.1186/s13072-024-00566-2
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