Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats

Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats

IntroductionEffects and interactions between different spaceflight stressors are expected to be experienced by crew on missions when exposed to microgravity and galactic cosmic rays (GCRs). One of the limitations of previous studies on simulated weightlessness using hindlimb unloading (HU) is that a...

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Main Authors: Jacob Raber, Mitali Chaudhari, Alexis De la Torre, Sarah Holden, Kat Kessler, Breanna Glaeser, Marek Lenarczyk, Scott Willem Leonard, Alexander Borg, Andy Kwok, Chirayu Patel, Amy Kronenberg, Christopher M. Olsen, Jeffrey S. Willey, Jeffrey Morré, Jaewoo Choi, Jan Frederik Stevens, Gerd Bobe, Jessica Minnier, John Baker
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Physiology
Subjects:
Fischer rats
5-ion beam irradiation
hindlimb unloading
open-field
object recognition
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1486767/full
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https://www.frontiersin.org/articles/10.3389/fphys.2024.1486767/full

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